Table 3.
Histomorphometrical values on the TNBS-induced colitis mice.
| Criteria | Control (untreated) | Control (EtOH) | TNBS | TNBS + 5′-ASA | TNBS + SEL001 |
|---|---|---|---|---|---|
| Ulcerative lesions (%)* | 2.36 ± 2.47 | 7.05 ± 1.70ad | 15.34 ± 4.75ace | 5.87 ± 1.22bf | 9.07 ± 2.36acf |
| Mucosa | |||||
| Thickness (μm) | 249.42 ± 13.15 | 208.79 ± 9.89ac | 100.50 ± 12.03ace | 246.45 ± 36.29ef | 151.36 ± 17.78acef |
| Inflammatory cells (/mm2) | 54.20 ± 14.86 | 227.40 ± 26.15hj | 460.40 ± 62.92hjl | 231.20 ± 28.26hjn | 343.00 ± 43.06hjlo |
| Microvessels (/mm2) | 10.80 ± 2.05 | 17.20 ± 4.87ik | 56.80 ± 12.79hjl | 24.40 ± 3.78hjmn | 29.80 ± 5.40hjmn |
| Mast cells (/mm2) | 27.60 ± 3.58 | 18.40 ± 2.97ac | 4.80 ± 0.84ace | 12.80 ± 1.64acef | 9.00 ± 1.58aceg |
| Collagen fibers (%) | 6.77 ± 3.12 | 14.38 ± 2.04ac | 25.68 ± 2.23ace | 16.51 ± 2.25acf | 19.29 ± 2.37acef |
Values are expressed as Mean ± S.D. of five histological fields.
*
Ulcerative lesions = [(Length of any desquamated lesions in crossly trimmed colon mucosa/Total cross length of colon mucosa (mm)] × 100.