Figure 5.

Genetically perturbed pathways in PMBL. Recurrent genetic drivers, including CCGs, SCNAs, and SVs, are visualized in their functional pathways. Note that certain drivers are perturbed by several genetic mechanisms and that several alterations converge on the level of a deregulated pathway (bold). Alterations that are known to inactivate the involved proteins are noted (┴). An asterisk (*) denotes all genes related to MHC class I and or MHC class II. A purple circle/box with a darker gray background highlights genes that are more frequently altered in PMBL compared with cHL. p, phosphorylation.