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. 2019 Dec 20;10:2975. doi: 10.3389/fimmu.2019.02975

Figure 5.

Figure 5

Albumin treatment to attenuate IRI. Human serum albumin (HSA) was given intravenously 10 min prior to IRI (45 min). The pro-inflammatory cytokine IL-6 and TNF-α mRNA expression was significantly decreased in the albumin treatment group compared to the vehicle at 2 h after IRI (A,B *p < 0.05). C5aR1 expression was significantly higher in vehicle treated IRI kidneys compared to control kidneys (C, *p < 0.05). C3aR mRNA expression was significantly reduced by albumin treatment compared to vehicle (D, *p < 0.05). The tubular function marker A1M showed higher expression after albumin treatment in proximal tubular epithelial cells after IRI (E–G, bar: 100 μm mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, n = 6 mice/group, one way ANOVA). n = 5 mice/group, one way ANOVA.