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The mechanism underlying the protective effects of melatonin on MSCs. Melatonin preconditioning exerts beneficial effects on MSCs through receptor‐dependent and receptor‐independent pathways. By eliminating ROS and up‐regulating the ERK1/2, AMPK/ACC, and PrPC/PINK1 signaling pathways, this method can facilitate cell survival and promote paracrine activity and mitochondrial function
