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Schematic mechanism of the cardioprotective effects of DEX through targeting HIF‐1α. A, Under normal conditions, HIF‐1α protein is degraded by PHDs. B, Under H/R conditions, HIF‐1α protein accumulates and exerts transcriptional activities. DEX down‐regulates the expression of HIF‐1α at the post‐transcriptional level and inhibits the transcriptional activation of BNIP3. DEX, dexmedetomidine; PHD, prolyl hydroxylase; and HRE, hypoxia reaction element
