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. 2019 Nov 20;24(1):276–284. doi: 10.1111/jcmm.14717

Figure 4.

Figure 4

Artesunate inhibited the nuclear localization of SREBP2. A, q‐PCR was performed to examine the effects of artesunate on the mRNA expression of HMGCR. B, A ChIP assay was performed to examine the effects of artesunate on the binding of SREBP2 to the HMGCR promoter. C, Immunofluorescence staining was performed to examine the effects of artesunate on the nuclear localization of SREBP2 in U87 cells; scale bar, 20 µm. D, IHC staining was performed to examine the effects of artesunate on the nuclear localization of SREBP2 in distant seeded metastatic foci; scale bar, 50 µm. *P < .05; **P < .01