Table 1.
Activity of IM1918 in an in vitro kinase assay
| Kinase | Activity (average, %) | Kinase | Activity (average, %) |
|---|---|---|---|
| FGFR3 | 63.91 ± 0.185 | ERK2/MAPK1 | 99.5 ± 0.695 |
| FGFR1 | 81.64 ± 2.185 | ALK | 99.71 ± 0.556 |
| p70S6K/RPS6KB1 | 85.35 ± 0.056 | GRK2 | 100.33 ± 1.444 |
| FYN | 85.89 ± 1.698 | ROS/ROS1 | 100.54 ± 2.611 |
| P38a/MAPK14 | 87.79 ± 7.829 | JAK3 | 100.84 ± 0.61 |
| YES/YES1 | 88.15 ± 1.999 | JNK3/MAPK10 | 100.89 ± 2.331 |
| ZAP70 | 89.47 ± 2.099 | AKT2 | 101.83 ± 3.632 |
| AKT1 | 90.26 ± 1.076 | FAK/PTK2 | 101.86 ± 0.26 |
| JAK1 | 91.38 ± 0.141 | TAK1/MAP3K7 | 101.95 ± 8.525 |
| IGF1R | 92.08 ± 1.335 | ASK1/MAP3K5 | 102.25 ± 0.841 |
| IKKb/IKBKB | 92.18 ± 2.026 | JNK1/MAPK8 | 102.42 ± 2.462 |
| PKA | 93.6 ± 1.914 | ERK1/MAPK3 | 102.6 ± 3.873 |
| PAK2 | 95.07 ± 1.978 | SRC/c‐Src | 102.66 ± 2.875 |
| SYK | 95.6 ± 3.765 | PYK2/PTK2B | 102.69 ± 0.918 |
| ROCK1 | 95.77 ± 1.82 | TYK2 | 102.83 ± 12.29 |
| JNK2/MAPK9 | 96.35 ± 2.736 | PDK1/PDPK1 | 105.71 ± 2.438 |
| FGFR2 | 96.77 ± 1.601 | TYK1/LTK | 106.77 ± 3.737 |
| TYRO3/SKY | 96.94 ± 0.975 | PAK1 | 107.06 ± 5.566 |
| JAK2 | 96.97 ± 8.383 | RAF1 | 107.28 ± 8.001 |
| BRAF | 97.74 ± 1.883 | IRAK4 | 109.78 ± 1.391 |
| P38b/MAPK11 | 98.61 ± 2.143 | ARAF | 119.05 ± 1.864 |
| TGFBR1/ALK5 | 98.88 ± 0.483 | TGFBR2 | 134.3 ± 2.88 |
| GSK3b | 99.19 ± 5.12 |