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Serum pattern of M1/M2 cytokines and nitrite levels. Cytokines and nitrite/nitrate levels were measured 24 h, 3, 5, 10 and 30 d after sepsis induction in the hippocampus of animals treated with or without minocycline. A, TNF; B, IL‐6; C, IL‐1; D, nitrite/nitrate; E, CCL‐22; F, IL‐10. *Different from that at 0 h (dotted line); # different from CLP + minocycline at the same time. Data are expressed as mean ± SD P < .05
