Table 3.
Association between inferred haplotypes of LIN28A gene and neuroblastoma susceptibility
| Haplotypesa | Cases (N = 1010) | Controls (N = 2140) | Crude OR (95% CI) | P |
Adjusted ORb (95% CI) |
P b |
|---|---|---|---|---|---|---|
| No. (%) | No. (%) | |||||
| GTGG | 642 (63.56) | 1467 (68.55) | 1.00 | 1.00 | ||
| GTGA | 2 (0.20) | 0 (0.00) | / | / | / | / |
| GTAG | 129 (12.77) | 218 (10.19) | 1.35 (1.07‐1.71) | .013 | 1.35 (1.07‐1.72) | .012 |
| GTAA | 1 (0.10) | 0 (0.00) | / | / | / | / |
| GCGG | 54 (5.35) | 123 (5.75) | 1.00 (0.72‐1.40) | .985 | 1.01 (0.72‐1.40) | .977 |
| GCGA | 2 (0.20) | 3 (0.14) | 1.52 (0.25‐9.14) | .645 | 1.51 (0.25‐9.04) | .655 |
| GCAG | 10 (0.99) | 18 (0.84) | 1.27 (0.58‐2.77) | .548 | 1.27 (0.58‐2.76) | .551 |
| GCAA | 1 (0.10) | 1 (0.05) | 2.29 (0.14‐36.59) | .559 | 2.29 (0.14‐36.71) | .558 |
| ATGG | 64 (6.34) | 124 (5.79) | 1.18 (0.86‐1.62) | .306 | 1.18 (0.86‐1.62) | .304 |
| ATGA | 0 (0.00) | 0 (0.00) | / | / | / | / |
| ATAG | 17 (1.68) | 21 (0.98) | 1.85 (0.97‐3.53) | .062 | 1.85 (0.97‐3.53) | .062 |
| ATAA | 0 (0) | 0 (0.00) | / | / | / | / |
| ACGG | 56 (5.54) | 121 (5.65) | 1.06 (0.76‐1.47) | .740 | 1.06 (0.76‐1.47) | .740 |
| ACGA | 16 (1.58) | 33 (1.54) | 1.11 (0.61‐2.03) | .740 | 1.11 (0.61‐2.04) | .728 |
| ACAG | 14 (1.39) | 10 (0.47) | 3.20 (1.41‐7.24) | .005 | 3.20 (1.41‐7.25) | .005 |
| ACAA | 2 (0.20) | 1 (0.05) | 4.57 (0.41‐50.49) | .215 | 4.54 (0.41‐50.19) | .217 |
Abbreviations: CI, confidence interval; OR, odds ratio.
Significance of bold values are the P values less than 0.05 or the 95% CIs excluded 1.
a
The haplotype order was rs3811464, rs3811463, rs34787247 and rs11247957.
b
Obtained in logistic regression models with adjustment for age and gender.