Figure 2.

Celastrol ameliorated CCl4‐caused liver injury in rats. Rats were grouped as follows: 1. control group (no CCl4, no treatment); 2. model group (with CCl4, no treatment); 3. celastrol (0.25 mg/kg) and CCl4 treated group; 4. celastrol (0.5 mg/kg) and CCl4 treated group; and 5. celastrol (1 mg/kg) and CCl4 treated group. A, Gross examination of rat livers. Representative photographs are shown (scale bar: 1 cm). B, Liver sections were stained with H&E for histological examination. Representative photographs are shown (scale bar: 100 μm). C, Determination of the serum levels of ALT, AST and ALP. D, The ratio of liver/body weight (%). Data are expressed as Mean ± SD, and each group had eight rats. Significance: **P < .01 and ***P < .001 vs the control group; #P < .05, ##P < .01 and ###P < .001 vs the model group