Table 3.

Meningococcal infections

Patient	Age group	Description
1	Pediatrica	•Pediatric patient 15 yr old with native kidneys and no ongoing dialysis at the time of infection •Vaccinated with Bexsero 2 wk after treatment initiation; no prophylactic antibiotics reported •Hospitalized for meningococcal serogroup B sepsis ≈21 mo after the first infusion of eculizumab •Following treatment with ceftriaxone, the infection resolved •Eculizumab therapy was not interrupted
2	Adultb	•Adult patient 22 yr old with native kidneys and no dialysis at the time of infection •Vaccinated with Bexsero 2 wk after treatment initiation and penicillin provided as prophylactic antibiotic •Hospitalized for meningococcal serogroup B infection ≈6 mo after the first infusion of eculizumab; the bacterial strain was determined to be penicillin-resistant •Following treatment with ceftriaxone, the infection resolved; the patient continued prophylactic treatment with penicillin •Eculizumab therapy was not interrupted
3	Adultc	•Adult patient 20 yr old with native kidneys and no dialysis at the time of infection •Vaccinated with Menactra but no antibiotic prophylaxis reported •Fulminant meningococcemia with Waterhouse−Friderichsen syndrome reported ≈8 mo after the first infusion of eculizumab •The patient reported symptoms of malaise, headache, fever, and stiffness, which progressed rapidly within 12 hr; the patient died the same day, of fulminant infection and sepsis •Tested negative for serogroups A, B, C, and W; disease was classified as “nontypable”; Neisseria infection confirmed by polymerase chain reaction •The patient had a simultaneous Staphylococcus haemolyticus infection

^aPatient was pediatric (<18 yr of age) at the time of registry enrollment.

^bCase details were reported previously by Parikh et al.³⁸

^cCase details were reported previously by Platonov et al.²¹