Hemodynamic data and NT-proBNP level before and after riociguat treatment. (A) NT-proBNP, (B) mPAP, (C) CO and (D) PVR before and after riociguat treatment. CO, cardiac output; MPAP, mean pulmonary artery pressure; NT-proBNP, N-terminal probrain natriuretic peptide; PVR, pulmonary vascular resistance.