Table 1.
FDR significant CpGs changed by HFHS diet in 45 strains of mice.
| Chr | BP | Median change by HFHS | t-test p-value | FDR | Annotated gene 1 | Distance to TSS | Annotated gene 2 | Distance to TSS |
|---|---|---|---|---|---|---|---|---|
| 1 | 73957398 | 0.14 | 6.28E-09 | 2.03E-04 | Tns1 | 167049 | Tnp1 | −941500 |
| 1 | 89466797 | 0.1 | 1.46E-05 | 4.26E-02 | Agap1 | 11987 | D130058E05Rik | −463437 |
| 1 | 90962615 | 0.125 | 4.50E-05 | 9.11E-02 | Rab17 | 7046 | Prlh | 9508 |
| 1 | 133264749 | 0.105 | 5.94E-06 | 2.28E-02 | Plekha6 | 18653 | Golt1a | −45074 |
| 1 | 151244113 | −0.12 | 4.65E-07 | 4.18E-03 | Ivns1abp | −100385 | Hmcn1 | −251063 |
| 10 | 63583522 | 0.05 | 1.53E-05 | 4.26E-02 | Ctnna3 | 126013 | Gm10118 | 343912 |
| 10 | 69248814 | −0.1 | 3.79E-05 | 8.28E-02 | Rhobtb1 | 35621 | Cdk1 | 104124 |
| 10 | 69248832 | −0.18 | 4.21E-06 | 2.03E-02 | Rhobtb1 | 35639 | Cdk1 | 104106 |
| 10 | 69248838 | −0.15 | 4.53E-06 | 2.03E-02 | Rhobtb1 | 35645 | Cdk1 | 104100 |
| 10 | 69248844 | −0.19 | 2.69E-09 | 1.09E-04 | Rhobtb1 | 35651 | Cdk1 | 104094 |
| 10 | 69248850 | −0.2 | 6.51E-07 | 5.26E-03 | Rhobtb1 | 35657 | Cdk1 | 104088 |
| 10 | 69248853 | −0.14 | 4.36E-06 | 2.03E-02 | Rhobtb1 | 35660 | Cdk1 | 104085 |
| 10 | 69248866 | −0.15 | 8.52E-06 | 2.87E-02 | Rhobtb1 | 35673 | Cdk1 | 104072 |
| 11 | 51785947 | 0.115 | 4.89E-06 | 2.13E-02 | Sar1b | 22261 | Phf15 | 71706 |
| 11 | 98877224 | 0.12 | 4.14E-05 | 8.82E-02 | Wipf2 | 13587 | Cdc6 | −30927 |
| 11 | 106818615 | 0.105 | 1.44E-05 | 4.26E-02 | Cep95 | 29341 | Smurf2 | 101855 |
| 11 | 107265371 | 0.14 | 5.06E-06 | 2.13E-02 | Nol11 | −75991 | Pitpnc1 | 205328 |
| 11 | 117233894 | −0.15 | 4.34E-06 | 2.03E-02 | 43717 | 34234 | Gm11733 | −250474 |
| 11 | 117820356 | 0.11 | 7.08E-07 | 5.45E-03 | Afmid | −5568 | Syngr2 | 10689 |
| 11 | 117820370 | 0.15 | 1.51E-08 | 2.92E-04 | Afmid | −5554 | Syngr2 | 10703 |
| 11 | 120821045 | −0.1 | 2.32E-06 | 1.34E-02 | Fasn | 3133 | Dus1l | −24651 |
| 12 | 73838480 | −0.225 | 6.33E-06 | 2.28E-02 | Hif1a | −69424 | Prkch | 253684 |
| 12 | 73838512 | −0.24 | 2.73E-05 | 6.61E-02 | Hif1a | −69392 | Prkch | 253716 |
| 12 | 82399195 | 0.105 | 1.51E-05 | 4.26E-02 | Sipa1l1 | 87847 | Gm5435 | 97342 |
| 12 | 84769968 | 0.13 | 1.62E-08 | 2.92E-04 | Npc2 | 3144 | Isca2 | −3302 |
| 12 | 85754916 | 0.08 | 4.16E-07 | 3.96E-03 | Mfsd7c | 8378 | 0610007P14Rik | 69606 |
| 12 | 85975275 | 0.12 | 2.12E-06 | 1.27E-02 | Tgfb3 | 103766 | Ttll5 | 150566 |
| 13 | 46615383 | 0.1 | 2.96E-06 | 1.65E-02 | C78339 | −54139 | Cap2 | 113536 |
| 14 | 63202824 | 0.155 | 7.48E-06 | 2.57E-02 | Neil2 | −9284 | Gata4 | 42424 |
| 15 | 7187724 | 0.16 | 3.01E-08 | 4.86E-04 | Lifr | 33372 | Egflam | 210580 |
| 15 | 38302403 | −0.14 | 1.94E-06 | 1.20E-02 | Klf10 | −1697 | ||
| 15 | 38302475 | −0.12 | 6.14E-07 | 5.23E-03 | Klf10 | −1769 | ||
| 15 | 38302543 | −0.07 | 3.57E-05 | 8.02E-02 | Klf10 | −1837 | ||
| 15 | 57936054 | −0.13 | 1.74E-06 | 1.13E-02 | Wdr67 | 23856 | Fam83a | −49365 |
| 15 | 85745965 | 0.08 | 4.49E-06 | 2.03E-02 | Ppara | 10190 | Cdpf1 | 65731 |
| 15 | 85745974 | 0.09 | 1.05E-06 | 7.08E-03 | Ppara | 10199 | Cdpf1 | 65722 |
| 15 | 85745987 | 0.13 | 2.04E-07 | 2.36E-03 | Ppara | 10212 | Cdpf1 | 65709 |
| 16 | 24391817 | 0.09 | 4.27E-05 | 8.98E-02 | Lpp | −1533 | ||
| 16 | 34113282 | 0.1 | 2.51E-05 | 6.25E-02 | Umps | −146245 | Kalrn | 400766 |
| 16 | 38432088 | 0.08 | 9.93E-06 | 3.15E-02 | Pla1a | 1057 | Popdc2 | 69880 |
| 17 | 28065710 | −0.07 | 2.51E-05 | 6.25E-02 | Tcp11 | 14874 | Anks1 | 156371 |
| 17 | 28065873 | −0.15 | 5.21E-08 | 7.67E-04 | Tcp11 | 14711 | Anks1 | 156534 |
| 17 | 28065883 | −0.09 | 5.14E-06 | 2.13E-02 | Tcp11 | 14701 | Anks1 | 156544 |
| 17 | 47442447 | 0.125 | 4.62E-05 | 9.23E-02 | 1700001C19Rik | −5073 | Taf8 | 59840 |
| 19 | 44414923 | −0.22 | 5.01E-11 | 2.70E-06 | Scd1 | −7215 | Wnt8b | −78549 |
| 19 | 44414943 | −0.25 | 3.18E-13 | 5.15E-08 | Scd1 | −7235 | Wnt8b | −78529 |
| 19 | 44414944 | −0.255 | 2.87E-12 | 2.32E-07 | Scd1 | −7236 | Wnt8b | −78528 |
| 19 | 44414952 | −0.15 | 1.33E-08 | 2.92E-04 | Scd1 | −7244 | Wnt8b | −78520 |
| 19 | 44414953 | −0.11 | 6.00E-08 | 8.09E-04 | Scd1 | −7245 | Wnt8b | −78519 |
| 19 | 53610483 | 0.14 | 6.18E-06 | 2.28E-02 | Smc3 | 10086 | Rbm20 | −66823 |
| 2 | 4891640 | 0.105 | 2.82E-05 | 6.72E-02 | Sephs1 | 10077 | Phyh | −27379 |
| 2 | 31488626 | 0.11 | 1.48E-05 | 4.26E-02 | Ass1 | 18420 | Fubp3 | −84099 |
| 2 | 31511721 | 0.13 | 3.36E-05 | 7.73E-02 | Ass1 | 41515 | Fubp3 | −61004 |
| 2 | 32417288 | 0.085 | 3.97E-05 | 8.56E-02 | Ptges2 | 21393 | Naif1 | −33169 |
| 2 | 32417292 | 0.09 | 9.93E-06 | 3.15E-02 | Ptges2 | 21397 | Naif1 | −33165 |
| 2 | 32928045 | −0.24 | 2.66E-07 | 2.87E-03 | Rpl12 | −33514 | Fam129b | 51932 |
| 2 | 155185551 | 0.09 | 4.36E-05 | 9.03E-02 | Dynlrb1 | −50984 | Itch | 51993 |
| 2 | 160741022 | 0.075 | 3.39E-05 | 7.73E-02 | Plcg1 | 9713 | Zhx3 | 118609 |
| 2 | 174858446 | −0.08 | 1.12E-05 | 3.47E-02 | Edn3 | 97828 | Gm14444 | −151873 |
| 3 | 88568840 | 0.19 | 7.19E-08 | 8.94E-04 | Ssr2 | −10831 | Ubqln4 | 15125 |
| 3 | 129421906 | −0.115 | 3.68E-06 | 1.98E-02 | Enpep | −89187 | Elovl6 | −110480 |
| 3 | 138224032 | 0.17 | 3.77E-05 | 8.28E-02 | Adh7 | 6210 | Adh1 | −53462 |
| 4 | 8748959 | 0.13 | 2.21E-05 | 5.72E-02 | Chd7 | 57595 | Clvs1 | −520358 |
| 4 | 41371302 | 0.125 | 3.96E-06 | 2.03E-02 | Ubap1 | 22307 | Kif24 | 93538 |
| 5 | 92365051 | −0.1 | 2.23E-05 | 5.72E-02 | Cxcl10 | −16170 | Nup54 | 70168 |
| 5 | 120483727 | 0.13 | 1.71E-05 | 4.68E-02 | Sds | 7197 | Plbd2 | 19898 |
| 5 | 123029761 | 0.085 | 8.85E-07 | 6.23E-03 | Orai1 | 14688 | Morn3 | 17255 |
| 5 | 125147678 | −0.11 | 3.21E-05 | 7.53E-02 | Ncor2 | 31375 | Fam101a | 144232 |
| 5 | 125463847 | 0.1 | 4.73E-05 | 9.33E-02 | Aacs | −11967 | Bri3bp | 22280 |
| 5 | 142593387 | 0.16 | 8.76E-09 | 2.36E-04 | Mmd2 | 15413 | Radil | −42290 |
| 5 | 142593399 | 0.08 | 9.27E-06 | 3.06E-02 | Mmd2 | 15401 | Radil | −42302 |
| 5 | 145871583 | 0.11 | 7.65E-07 | 5.62E-03 | Cyp3a11 | 8381 | Cyp3a44 | −65710 |
| 5 | 146005723 | 0.16 | 3.51E-07 | 3.54E-03 | Cyp3a25 | 3894 | Cyp3a11 | −125760 |
| 5 | 146005929 | 0.12 | 6.54E-06 | 2.30E-02 | Cyp3a25 | 3688 | Cyp3a11 | −125966 |
| 5 | 149008580 | −0.145 | 4.98E-05 | 9.70E-02 | Hmgb1 | 44460 | Gm15409 | 49303 |
| 7 | 80219975 | 0.1 | 6.03E-06 | 2.28E-02 | Cib1 | 12838 | Sema4b | 33135 |
| 7 | 98352904 | 0.09 | 4.46E-05 | 9.11E-02 | Tsku | 8384 | Acer3 | −43367 |
| 8 | 119442446 | 0.14 | 1.14E-05 | 3.47E-02 | Necab2 | −4273 | ||
| 8 | 122231359 | 0.135 | 5.38E-06 | 2.17E-02 | Banp | 280816 | Gm22 | −38210 |
| 9 | 21632184 | −0.155 | 1.78E-05 | 4.80E-02 | Smarca4 | 16016 | Ldlr | −91392 |
| 9 | 42461997 | 0.115 | 6.25E-06 | 2.28E-02 | Tbcel | 10261 | Tecta | −62069 |
| 9 | 46243778 | −0.11 | 2.74E-05 | 6.61E-02 | Apoa4 | 3083 | Apoa5 | −24855 |
| 9 | 108378240 | 0.11 | 2.13E-05 | 5.66E-02 | 1700102P08Rik | −14594 | Usp4 | 30410 |