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. 2019 Dec 20;10:1544. doi: 10.3389/fphys.2019.01544

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Copyright © 2019 Vajente, Norante, Redolfi, Daga, Pizzo and Pendin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ca²⁺ dynamics induced by (A,B) ionomycin, (C,D) CPA, (E,F) ionomycin after CPA-induced ER depletion in neurons dissociated from larval brains expressing spastin^K467R, and relative controls, detected by fura-2. (A,C,E) Cells were stimulated with (A,E) 10 μM ionomycin or (C) 50 μM CPA in the presence of extracellular Ca²⁺ chelator EGTA. In all panels, average traces are represented as R/R₀ values of n > 100 cells. (B,D,F) Histograms report the average area under curve (AUC) values of the traces recorded. Data are presented as mean ± SEM of n > 100 cells. ***p < 0.001.