FIG. 5.
The PK–PD model used to describe the changes in ICSS threshold after exposure to cannabis smoke. A three-compartment model was used to describe the PKs. The mass transfer between the compartments was described by intercompartmental clearances (Q2 and Q3) and elimination from central compartment (plasma) is given by CL. Ke0 describe the rate of transfer of drug from the central to effect compartment. The concentration in the effect compartment is the driver for lowering the ICSS threshold after smoke exposure. PD, pharmacodynamic; PK, pharmacokinetic.