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Summary of Exposure Parameters of THC After Intravenous Administration and Cannabis Smoke Inhalation
| PK parameter | THC IV | THC inhalation | THC inhalation |
|---|---|---|---|
| Dose (mg/kg) | 1 | 0.05 | 0.2 |
| Half-life (h) | 1.90±0.3 | 3.00±0.8 | 3.30±0.7 |
| CL (L/h) | 1.13±0.0 | 1.10±0.1 | 1.40±0.1 |
| VolumeSS (L) | 3.09±0.5 | 3.30±1.0 | 4.10±0.1 |
| AUC0−t (h×μg/L) | 259.10±4.5 | 12.40±1.7 | 38.20±3.8 |
| AUCinf (h×μg/L) | 263.05±3.9 | 13.10±1.6 | 41.40±4.7 |
PK, pharmacokinetic; THC, delta 9-tetrahydrocannabinol.
