Table 1.

Description of studies.

Study	Population setting/N	Condition of interest/age group	Outcome measures	Intervention/time	Supervision/ Contact method	Design/Control group (CG)	Measurement time	Follow-up
Rojas et al. (33) [protocol]	Public primary care centers/ N = 434	Depressive symptomatology/18-65 years old	Primary outcome: depressive symptoms (PHQ-9) Secondary outcomes: health-related quality of life; service use; patient satisfaction; psychotherapy outcomes (OQ 45.2)	16-h training program for primary care teams (detection, diagnosis, and treatment of depression)	Research team/web-based platform and call center	Two-arm, single-blind CG: usual care (n = 217)	Baseline and follow-up	3, 6, and 12 months after baseline assessment
Carrasco (31)	Private and public outpatient health centers patients and therapists/ Patients N = 15; Therapists N = 5	Mild or moderate depression/female adolescents (12–18 years old)	Acceptability scale Interviews with therapists	Online video game	Research team/web-based platform (patients); in person (therapists)	Acceptability study CG: No control group	Post-intervention	No
Espinosa et al. (32)	Private outpatient clinic/ N = 35	Major depression (discharged patients)/ 18-65 years old	Acceptability and satisfaction questionnaire Semi-structured interviews	Web-based program for supporting and monitoring of depressive patients after treatment; 9 months	Research team/web-based platform and e-mail	Feasibility and acceptability study CG: No control group	Post-intervention	No
Gaete et al. (30) [protocol]	Public primary schools/ N = 4485	Bullying victims and perpetrators/5th and 6th grades (10-12 years old)	Primary outcomes: bullying and victimization (Revised Olweus Bully/Victim Questionnaire, OBVQ) Secondary outcomes: psychosocial adjustment, psychological sense of school membership, academic performance	Ten 2-h lessons delivered by trained teachers, posters encouraging to support victims, discussion groups, online game; 1 year Partial KiVa group: without online game (n = 1495)	Research team/in person	Three-arm, single-blind (blinded only to the outcome evaluator), cluster RCT CG: usual management for bullying (n = 1495)	Baseline and post-intervention	No
Rojas et al. (28)	Community hospitals located in rural areas/ N = 250	Major depressive disorder/18-70 years old	Primary outcome: depressive symptoms (Beck Depression Inventory, BDI-I) Secondary outcomes: health-related quality of life; treatment adherence to antidepressants; service use; patient satisfaction	Remote supervision by a psychiatrist through an electronic platform and/or telephone; 6 months	Research team/online and phone call	Nonrandomized, open-label (blinded outcome assessor) trial, two-arm CG: usual care (n = 139)	Baseline and follow-up	3 and 6 months after assignment
Martínez et al. (29)	Public primary care centers/ N = 143	Major depressive disorder/13-19 years old	Primary outcome: depressive symptoms (Beck Depression Inventory, BDI) Secondary outcomes: health-related quality of life; patient adherence and satisfaction; clinician satisfaction	Remote collaborative depression care (primary health care teams received remote supervision by a psychiatrist through a shared electronic health record and phone patient monitoring); 3 months	Research team/online and phone call	Cluster randomized, assessor-blind trial, two-arm CG: enhanced usual care (n = 78)	Baseline and follow-up	12 weeks
Mascayano et al. (34) [protocol]	Public high-schools/ N = 428	Suicidal ideation/14-18 years old	Primary outcome: Suicidality (Okasha Questionnaire) Secondary outcomes: impulsivity; self-esteem; stigma-discrimination; depressive symptoms; anxiety; utility and functionality	Project Clan (web-based platform and mobile app to cultivate a community to promote protective psychological and social factors); 3 months	Psychologist as online counselor/web platform	Two-arm, cluster RCT; participative approach (peer-adolescent) CG: adolescents without intervention (n = 214)	Baseline, post-intervention, and follow-up	2 month
Martínez et al. (under review)	Public and semi-private high-schools from Chile and Colombia/ N = 199	Moderate depressive symptomatology/14-17 years old	Primary outcome: depressive symptoms (Patient Health Questioner, PHQ-9) Secondary outcomes: automatic thoughts, social problem-solving, health-related quality of life	Stepped-care program according to PHQ-9 score: psychoeducational information, symptom monitoring with personalized automatic feedback, group forum and chat, reference to face-to-face attention if required; 12 weeks, with subsequent bi-monthly reinforcement sessions	Research team/email and chat	Feasibility and acceptability study CG: No control group	Baseline, post-intervention and follow-up	6 months after intervention
Irarrázaval et al. (under review)	Public primary health care center	Children and adolescents living in substitute care facilities	Primary outcome: case resolutions (e.g. number of cases with positive resolution) Secondary outcomes: usefulness and acceptability	90-minute online mental health supervision (diagnostic assistance, management guidance, assessment in referral to specialized services); twice a month for 6 months	Psychiatrist/ videoconference and online shared clinical record system	Quasi-experimental design and acceptability study CG: No control group	Pre-post test	No