Table 1.

Frequency of different endocrinopathies.

		CTLA-4 inhibitor	PD-1/PD-L1 inhibitor
Pituitary	Hypophysitis/hypopituitarism	+++	–
	Isolated ACTH deficiency	+	++
Thyroid	Thyroiditis/transient hyperthyroidism	++	+++
	Hypothyroidism	++	+++
	Graves’ disease/thyroid eye disease	+	?
Pancreas	Insulin-deficient diabetes	–	++
Adrenal	Primary adrenal insufficiency	+	+

ACTH: adrenocorticotropic hormone; CTLA-4: cytotoxic T-cell lymphocyte antigen-4; PD-1/PD-L1: program death-1 receptor or ligand.

⁺⁺⁺>5%.

⁺⁺0.5–5%.

⁺<0.5%.

^?Unknown.

^–Not described.