Table 2.
Association between SPP1 SNPs and the risk of BRC.
| SNPs | Controls | Cases | OR | P-value† |
|---|---|---|---|---|
| (n = 471) | (n = 471) | (95% CI)† | ||
| rs11730582 | ||||
| TT | 213 (45.2) | 241 (51.2) | 1.00 (reference) | |
| TC | 204 (43.3) | 194 (41.2) | 0.84 (0.64–1.09) | 0.208 |
| CC | 54 (11.5) | 36 (7.6) | 0.59 (0.37–0.94) | 0.026 |
| CC + TC vs. TT | 0.79 (0.61–1.02) | 0.070 | ||
| CC vs. TC + TT | 0.64 (0.41–1.01) | 0.052 | ||
| T | 630 (66.9) | 676 (71.8) | 1.00 (reference) | |
| C | 312 (33.1) | 266 (28.2) | 0.79 (0.65–0.96) | 0.022 |
| rs2853750 | ||||
| AA | 143 (30.4) | 148 (31.4) | 1.00 (reference) | |
| AG | 234 (49.7) | 232 (49.3) | 0.95 (0.71–1.28) | 0.782 |
| GG | 94 (19.9) | 91 (19.3) | 0.93 (0.64–1.34) | 0.729 |
| GG + AG vs. AA | 0.95 (0.72–1.25) | 0.733 | ||
| GG vs. AG + AA | 0.96 (0.70–1.33) | 0.817 | ||
| A | 520 (55.2) | 528 (56.1) | 1.00 (reference) | |
| G | 422 (44.8) | 414 (43.9) | 0.96 (0.80–1.16) | 0.723 |
| rs35893069 | ||||
| AA | 132 (28.0) | 136 (28.9) | 1.00 (reference) | |
| AT | 242 (51.4) | 234 (49.7) | 0.94 (0.69–1.26) | 0.660 |
| TT | 97 (20.6) | 101 (21.4) | 1.01 (0.70–1.44) | 0.991 |
| TT + AT vs. AA | 0.96 (0.72–1.28) | 0.761 | ||
| TT vs. AT + AA | 1.06 (0.77–1.44) | 0.729 | ||
| A | 506 (53.7) | 506 (53.7) | 1.00 (reference) | |
| T | 436 (46.3) | 436 (46.3) | 1.01 (0.84–1.20) | 0.970 |
OR, odds ratio; SPP1, secreted phosphoprotein-1; SNP, secreted phosphoprotein-1; BRC, breast cancer.
†
Adjusted by age at diagnosis and age at menarche.
P < 0.05 was indicated in bold.