Table 1.
Baseline characteristics of the included publications.
| References | Country | Median age | N(F/M) | Smoking (S/NS) | Histology | Stage | MET type | Antibody | Cut-off value | MET high | MET low | HR estimation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tsakonas et al. (25) | Sweden | 66.5 | 653 (316/337) | 589/64 | NSCLC | IA–IIIB | c-MET | PharmDx | H-score ≥ 20 | 336 | 117 | Multi |
| Zhang et al. (45) | China | 60.4 | 86 (44/42) | 29/57 | ADCC | I–IV | c-MET | RM (SP44) | Staining score ≥ 2+ (50%) | 54 | 32 | Multi |
| Kim et al. (46) | Korea | NR | 311 (140/171) | 109/202 | ADCC | IB–IIIA | c-MET | RM (SP44) | Staining score ≥ 2+ (50%) | 141 | 170 | Multi |
| Tran et al. (24) | Australia | 67 (–)/ 69 (+) | 271 (98/173) | 211/9 | NSCLC | I–III | c-MET | RM (SP44) | Staining score ≥ 2+ (50%) | 248 | 23 | Multi |
| Tong et al. (44) | China (HK) | 66 | 687 (223/464) | 395/223 | NSCLC | I–IV | c-MET | RM (SP44) | Staining score ≥ 2+ (50%) | 230 | 457 | Uni |
| Wang et al. (43) | China | 57 | 117 (33/84) | 43/74 | NSCLC | I–IV | c-MET | R* | H-score ≥ 1.9 | 36 | 81 | Multi |
| Huang et al. (23) | China | 62 | 102 (29/73) | 47/55 | NSCLC | I–IV | c-MET | RM | H-score ≥ 60 | 52 | 50 | Multi |
| Sun et al. (39) | China | 56.2 | 183 (42/141) | 117/66 | ADCC/SCC | I–IV | c-MET | R* | Staining score > 3 | 123 | 60 | Multi |
| Tsuta et al. (30) | Japan | 61.7 | 906 (332/574) | 416/490 | NSCLC | I–IV | c-MET | RM | stained cells ≥ 10%/MA | 196 | 687 | Uni |
| p-MET | RM | stained cells ≥ 10%/MA | 51 | 829 | Uni | |||||||
| Tachibana et al. (29) | Japan | 64 | 106 (55/51) | 55/51 | ADCC | I–III | c-MET | RP | H intensity ≥ 2+ | 30 | 76 | Uni |
| Park et al. (27) | Korea | 62 | 380 (72/308) | 279/101 | ADCC/SCC | I–IV | c-MET | RP | H-score ≥ 4 | 52 | 328 | Multi |
| Dziadziuszko et al. (48) | Poland | 63 | 174 (39/135) | 165/9 | NSCLC | I–IV | c-MET | RM (SP44) | H-score > 60 | 83 | 91 | Uni |
| Onitsuka et al. (26) | Japan | 68.5 | 183 (81/102) | NR | ADCC | I–III | p-MET | M* | IHC Allred score ≥ 3 | 12 | 171 | Multi |
| Ruiz et al. (47) | Netherlands | NR | 168 | NR | NSCLC | I–III | p-MET | NR | H-score > 5 | 72 | 96 | Multi |
| Masuya et al. (42) | Japan | NR | 88 | NR | NSCLC | I–III | c-MET | RP | H intensity > grade 1 | 36 | 52 | Uni |
| Tokunou et al. (41) | Japan | 59 | 131 (58/73) | NR | ADCC | I–IV | c-MET | RP | Stained bundles ≥ 1/MA | 69 | 62 | Multi |
| Takanami et al. (40) | Japan | 61 | 120 (51/69) | NR | ADCC | I–IV | c-MET | RP (C-28) | Stained cells ≥ 25%/MA | 67 | 53 | Multi |
N, Number of patients; F, Female; M, Male; S, Smoker; NS, Non-smoker; NSCLC, Non-small cell lung cancer; ADCC, Adenocarcinoma; SCC, Squamous cell carcinoma; RM, Rabbit monoclonal; RP, Rabbit polyclonal; R*, Rabbit; M*, Monoclonal; NR, Not reported; MM, Mouse monoclonal; MA, Microscopic area; Multi, Multivariate analysis; Uni, Univariate analysis.