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. 2019 Dec 20;9:1450. doi: 10.3389/fonc.2019.01450

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Copyright © 2019 Kong, Li, Liu, Cui, Wang, Zhang, Tang, Du, Liu, Wu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SIX1 activated STAT3 signaling pathway to promote PTC cells proliferation via EYA1. Immunofluorescence show the co-localization of SIX1 (red) and EYA1 (green) (A). The relative mRNA level of SIX1 and EYA1 in PTC cell lines with SIX1 overexpression or silencing (B). Western blot analysis of indicated protein from PTC cells with SIX1 overexpression or silencing (C). Western blot analysis of indicated protein from BCPAP cells with SIX1 and/or EYA1 silencing (D). Western blot analysis of indicated protein from TPC-1 cells with EYA1 silencing (E). ^*p < 0.05.