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. 2019 Dec 20;9:1450. doi: 10.3389/fonc.2019.01450

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Copyright © 2019 Kong, Li, Liu, Cui, Wang, Zhang, Tang, Du, Liu, Wu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing SIX1 suppressed tumor growth as well as STAT3 signal in vivo. TPC-1 cells with SIX1 silencing or vector control were implanted into immunodeficiency mice, the body weight (A) and tumor volume (B) was monitored (n = 20). Representative tumor image (C) and quantitative analysis (n = 20) (D) were showed. Western blot analysis of total protein from tumor tissue (E) and relative quantitative analysis (n = 3) (F). ^*p < 0.05.