Table 1.

Means and standard deviations by diagnostic group (cognitively normal or symptomatic), sex, and Aβ/P-tau status for demographics; memory and global cognitive scores, hippocampal and total intracranial volumes; and number of APOE ε4 carriers

	Cognitively normal (CN)				Symptomatic patients
	Men		Women		Men			Women
	Aβ/P-tau+	Aβ/P-tau−	Aβ/P-tau+	Aβ/P-tau−	Aβ/P-tau+	Aβ/P-tau−		Aβ/P-tau+	Aβ/P-tau−
	(N = 16)	(N = 82)	(N = 29)	(N = 123)	(N = 108)	(N = 126)		(N = 88)	(N = 110)
Age	74.38 (4.40) b	72.40 (4.58) b	74.38 (4.34) b	74.03 (5.31) b	72.43 (5.18) a,b	69.84 (5.61) a,b		71.12 (5.05) a,b	69.08 (5.68) a,b
Education	14.12 (4.29)	12.17 (3.58)	11.97 (4.23)	12.08 (3.30)	11.65 (3.58)	11.63 (3.69)		11.51 (3.31)	12.18 (3.28)
ADAS Delayed Word Recall Omissions (/10)	3.31 (2.39)	2.12 (1.63)	2.07 (2.17)	1.74 (1.91)	6.00 (2.39)	4.90 (2.37)		6.50 (2.40)	3.50 (2.46)
MMSE total score	28.69 (0.87)	29.09 (0.98)	29.17 (0.76)	28.91 (0.99)	27.19 (1.80)	28.11 (1.78)		27.1 (1.78)	28.31 (1.57)
Total intracranial volume	1.7 × 106 (1.5 × 105)	1.7 × 106 (1.3 × 105)	1.5 × 106 (9.7 × 104)	1.5 × 106 (1.1 × 105)	1.7 × 106 (1.2 × 105)	1.7 × 106 (1.4 × 105)		1.5 × 106 (1.2 × 105)	1.5 × 106 (1.2 × 105)
Total hippocampal volume	7.8 × 103 (1.0 × 103)	7.7 × 103 (1.1 × 103)	7.0 × 103 (8.9 × 102)	7.1 × 103 (9.1 × 102)	6.8 × 103 (1.1 × 103)	7.4 × 103 (1.3 × 103)		6.3 × 103 (1.1 × 103)	7.1 × 103 (1.1 × 103)
APOE ε4 carriers	12 a	16 a	16 a	23 a	76 a	34 a		63 a	27 a

Abbreviations: Aβ/P-tau+ amyloid beta/P-tau positive, ADAS Alzheimer’s Disease Assessment Scale, APOE apolipoprotein E, MMSE Mini-Mental State Examination

^aDiffers by Aβ/P-tau+ within diagnostic group, p < 0.001

^bDiffers by sex within diagnostic group, p < 0.05

Significant differences in these variables by Aβ/P-tau status and sex within each diagnostic group are indicated by superscript