Table 3.

Results for regression models with sex, diagnosis (cognitively normal or symptomatic), Aβ/P-tau status, and their interactions predicting recall omissions on the ADAS word recall task and total hippocampal volume

Variable	ADAS 10 Word Recall Omissions
	Estimate	p
Intercept	0.56	0.704
Diagnosis (0 = CN, 1 = symptomatic)	2.51	< 0.001
Age	0.0088	0.61
Education	−0.107	< 0.001
Total intracranial volume (z-scored)	0.225	0.039
Sex (0 = male)	0.22	0.74
Hippocampal volume (z-scored)	−0.781	< 0.001
APOE ε4 Genotype (0 = no ε4)	0.049	0.79
CSF Aβ/P-tau positivity (Aβ/P-tau+) (0 = not Aβ/P-tau+)	1.97	0.10
Aβ/P-tau+ × diagnosis	−0.63	0.33
Aβ/P-tau+ × sex	−4.05	0.008
Diagnosis × sex	−0.76	0.06
Aβ/P-tau+ × diagnosis × sex	2.92	< 0.001
Variable	Total hippocampal volume
	Estimate	p
Intercept	10,938	< 0.001
Diagnosis (0 = CN, 1 = symptomatic)	− 547	< 0.001
Age	−82.8	< 0.001
Education	5.00	0.64
Total intracranial volume (z-scored)	0.0019	< 0.001
Sex (0 = male)	− 166	0.59
APOE ε4 Genotype (0 = no ε4)	20.7	0.81
Aβ/P-tau+ (0 = not Aβ/P-tau+)	453	0.42
Aβ/P-tau+ × diagnosis	− 401	0.18
Aβ/P-tau+ × sex	−72.1	0.92
Diagnosis × sex	77.8	0.68
Aβ/P-tau+ × diagnosis × sex	−76.0	0.84

Abbreviations: Aβ/P-tau+ amyloid beta/P-tau positivity, ADAS Alzheimer’s disease Assessment Scale, APOE apolipoprotein E, CN cognitively normal, CSF cerebrospinal fluid, MMSE Mini-Mental State Examination

significant p values had been bolded (p < .05)