Table 4.
Results for secondary regression model with sex, diagnosis (cognitively normal, subjective cognitive decline, or mild cognitive impairment), Aβ/Ptau status, and their interactions predicting recall omissions on the ADAS word recall task
| Variable | ADAS 10 Word Recall Omissions | |
|---|---|---|
| Estimate (CI) | p | |
| Intercept | −.986 (−2.14–4.90) | 0.454 |
| Diagnosis (1 = CN, 2 = SCD, 3 = MCI) | 1.75 (1.44–2.07) | < 0.001 |
| Age | 0.03 (−0.00–0.60) | 0.035 |
| Education | −0.07 (−0.12 to − 0.03) | < 0.001 |
| Total intracranial volume (z-scored) | 0.081 (−0.12–0.28) | 0.419 |
| Sex (0 = male) | −0.40 (−1.31–0.51) | 0.392 |
| Hippocampal volume (z-scored) | − 0.517 (− 0.70 to − 0.34) | < 0.001 |
| APOE ε4 genotype (0 = no ε4) | 0.01 (− 0.33–0.35) | 0.96 |
| CSF Aβ/P-tau positivity (Aβ/P-tau+) (0 = not Aβ/P-tau+) | 0.64 (− 0.77–2.04) | 0.376 |
| Aβ/P-tau+ × diagnosis | 0.03 (− 0.54–0.60) | 0.92 |
| Aβ/P-tau+ × sex | − 1.50 (− 3.32–0.32) | 0.108 |
| Diagnosis × sex | −0.20 (− 0.65–0.26) | 0.398 |
| Aβ/P-tau+ × diagnosis × sex | 1.03 (0.25–1.82) | 0.01 |
Note: Estimates, confidence intervals, and p values were calculated for each regression model
Abbreviations: Aβ/P-tau+ amyloid beta/P-tau positive, ADAS Alzheimer’s Disease Assessment Scale, APOE apolipoprotein E, CSF cerebrospinal fluid, MMSE Mini-Mental State Examination