. Author manuscript; available in PMC: 2019 Dec 27.

Published in final edited form as: Cogn Affect Behav Neurosci. 2019 Aug;19(4):1047–1058. doi: 10.3758/s13415-019-00704-4

Table 1.

Demographic, substance use, and clinical characteristics

Descriptive	CON		MJ		MDD		MDD+MJ		MDD effect		MJ effect		Interaction effect

									(CON and MJ vs.		(CON and MDD vs.

	(n=48)		(n=46)		(n=23)		(n=24)		MDD and MDD+MJ)		MJ and MDD+MJ)		MJ effect within MDD status

									p	ES	p	ES	p	ES CON	ES MDD

Demographics
Male (%, n)	48	(23)	52	(24)	52	(12)	48	(11)		1.00		1.00		1.19	0.84
Age (years)	21.5	(2.0)	20.3	(2.1)	22.1	(2.5)	21.3	(2.4)	^*	0.35	^*	−0.48		−0.60	−0.32
Education completed (years)	15.1	(1.9)	13.8	(1.7)	15.7	(2.1)	14.6	(1.6)		0.32	^***	−0.66		−0.72	−0.57
Predicted FSIQ (WTAR), M(SD)	113.9	(4.3)	114.1	(6.0)	110.0	(10.0)	109.6	(9.5)	^**	−0.60		−0.01		0.04	−0.05
Current SCID diagnoses
Alcohol abuse (%, n)	0	(0)	0	(0)	9	(2)	13	(3)	.	.	.	.	.	.
Alcohol dependence (%, n)	0	(0)	0	(0)	9	(2)	0	(0)	.	.	.	.	.	.
Marijuana abuse (%, n)	0	(0)	33	(15)	0	(0)	67	(16)	.	.	.	.	.	.	.
Marijuana dependence (%, n)	0	(0)	7	(3)	0	(0)	54	(13)	.	.	.		.	.		.	.
Major depressive disorder (%, n)	0	(0)	0	(0)	39	(9)	29	(7)	.	.	.	.		.	.
Any anxiety disorder (%, n)	0	(0)	0	(0)	48	(11)	54	(13)	.	.	.	.	.	.	.
Substance use
Alcohol
Drinks/week (TLFB)	2.3	(2.2)	3.2	(3.3)	2.1	(2.4)	4.8	(4.4)		0.24	^**	0.50		0.34	0.76
AUDIT score	3.1	(2.1)	4.1	(2.0)	3.4	(3.8)	4.0	(2.5)		0.05		0.35		0.50	0.17
Marijuana use (TLFB)
# MJ use days per week	.	.	3.0	(1.6)	.	.	4.8	(1.4)	^***	1.24		n/a		n/a	n/a
# MJ joints per week	.	.	7.8	(8.4)	.	.	17.3	(20.0)	^**	0.71		n/a		n/a	n/a
Age of onset (years)	.	.	16.2	(1.6)	.	.	16.4	(1.8)		0.09		n/a		n/a	n/a
Years of regular use, years	.	.	2.0	(1.4)	.	.	2.7	(2.6)		0.36		n/a		n/a	n/a
Recency of MJ use, days	.	.	2.0	(2.2)	.	.	1.1	(0.9)	^*	−0.51		n/a		n/a	n/a
Depressive Symptoms
MASQ¹
Anxious Symptoms	15.9	(4.3)	19.8	(5.3)	23.4	(7.3)	24.2	(8.0)	^***	0.98		0.42		0.82	0.10
Anxious Arousal	20.3	(2.9)	22.8	(5.9)	26.7	(7.4)	28.2	(10.1)	^***	0.88		0.35		0.58	0.17
Depressive Symptoms	18.0	(6.0)	21.5	(6.7)	37.6	(11.1)	30.9	(10.1)	^***	1.65		0.01	^**	0.57	−0.63
Anhedonic Depression	56.4	(12.7)	52.5	(13.3)	75.5	(13.0)	65.6	(15.4)	^***	1.12	^*	−0.31		−0.31	−0.69

Note. All values are means and standard deviations unless otherwise noted. P-values are based on ANOVA main effects and interactions for continuous variables and on logistic regression main effects or interactions for categorical variables, where

< 0.05,

^**

< 0.01,

^***

< 0.001. As for the SCID diagnoses, significance and effect sizes could not be estimated due to most diagnoses being specific to only some of the groups (i.e., quasi-complete separation issues in logistic models). Effect sizes (ES) are Cohen’s d for continuous variables and odds ratios for categorical variables CON healthy controls, MJ marijuana users without lifetime MDD, MDD non-users with lifetime MDD, MDD+MJ MJ users with lifetime MDD, FSIQ(WTAR) full-scale IQ, as estimated by the Wechsler Test of Adult Reading, AUDIT Alcohol Use Disorder Identification Test, TLFB time-line follow-back, MASQ Mood and Anxiety Symptom Questionnaire

MASQ was completed by 32 CON and 21 MJ because the questionnaire was introduced later in the study protocol