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. 2019 Dec 16;4(26):22245–22250. doi: 10.1021/acsomega.9b03797

Figure 2.

Figure 2

Solution conformations of lorlatinib in D2O/DMSO-d6 (blue) and CDCl3 (pink) aligned with the predicted conformations (gray). (A) 1 vs P1 in aqueous solution, (B) 1 vs P1 (left), and 2 vs P2 (right) in chloroform.