Figure 2.

Solution conformations of lorlatinib in D2O/DMSO-d6 (blue) and CDCl3 (pink) aligned with the predicted conformations (gray). (A) 1 vs P1 in aqueous solution, (B) 1 vs P1 (left), and 2 vs P2 (right) in chloroform.

Solution conformations of lorlatinib in D2O/DMSO-d6 (blue) and CDCl3 (pink) aligned with the predicted conformations (gray). (A) 1 vs P1 in aqueous solution, (B) 1 vs P1 (left), and 2 vs P2 (right) in chloroform.