Table 2. Kinetic Parameters of Selected Chromenones.
| AChE |
MAO-B | MAO-A | ||
|---|---|---|---|---|
| compd | Ki ± SE (μM) | αKi ± SE (μM) | IC50 ± SE (μM) | IC50 ± SE (μM) |
| 3 | 1.15 ± 0.27 | 2.82 ± 0.16 | 19.6 ± 0.9 | n.d.a |
| 7 | n.d. | n.d. | 7.20 ± 0.41 | n.d. |
| 8 | 1.26 ± 0.28 | 3.80 ± 0.61 | n.d. | n.d. |
| 9 | n.d. | n.d. | 6.73 ± 0.80 | n.d. |
| 10 | n.d. | n.d. | 1.18 ± 0.04 | 1.70 ± 0.22 |
| 11 | 18.6 ± 12.4 | 13.5 ± 4.1 | n.d. | n.d. |
| 15 | 2.06 ± 0.56 | 5.36 ± 0.70 | n.d. | n.d. |
| 20 | 1.61 ± 1.44 | 5.23 ± 1.46 | n.d. | n.d. |
| 21 | n.d. | n.d. | 3.99 ± 0.42 | n.d. |
| 24b | 4.70 ± 1.46 | 13.1 ± 2.5 | 19.9 ± 2.6 | 30.1 ± 3.2 |
| 27 | 9.23 ± 5.01 | 19.0 ± 4.1 | n.d. | n.d. |
a
Not determined.
b
Kinetic parameters of 24 at BChE: Ki ± SE = 0.0887 ± 0.0470 μM; αKi ± SE = 0.446 ± 0.088 μM. A selectivity ratio Ki(AChE)/Ki(BChE) of 53 was determined for 24.