Figure 1.

Detection of mRNAs for ERα and ERβ5 in endometrial cancers. Expression of ERα/ERβ5 mRNA is altered in women with endometrial cancer compared to post menopausal controls (PMCs). Expression of ERα mRNA (A) and ERβ5 mRNA (B) in PMCs (n = 9), G1 well differentiated (n = 19), G2 moderately differentiated (n = 52) and G3 poorly differentiated (n = 30). Total RNA for ERα in G1, G2, and G3 (P < 0.0001) were significantly lower than PMCs. Expression of ERβ5 mRNA appeared to increase in G3 compared to PMC but did not reach significance. Results are expressed as fold difference compared to PMCs with statistical analysis performed by one-way ANOVA with Tukey’s post hoc test, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.