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. 2019 Dec 9;13(12):14377–14387. doi: 10.1021/acsnano.9b07836

Figure 8.

Figure 8

Cytotoxicity of molecular nanomachine treatment for J774A.1 macrophages. Percent cytotoxicity of macrophage cells measured with an LDH assay at 0.5, 4, and 24 h exposed to 100 μM MNM without or with light activation. Percent cytotoxicity was calculated using a low control (natural cell death) (0%) and a high control (Triton-x induced cell death) (100%) (a) without MNM (1% DMSO) (p = 0.0282), (b) with 100 μM of MNM 1 (fast motor) in 1% DMSO (p = 0.0428), (c) with 100 μM of MNM 2 (slow motor) in 1% DMSO (p = 0.1971), (d) with 100 μM of MNM 3 (fast motor with TPP, targeting mitochondria) in 1% DMSO (p = 0.8748). The DMSO concentration was 1% because 100 μM MNM was assayed. Results presented are mean and standard error from four replicates; *p < 0.05.