Skip to main content
. 2019 Nov 21;8(12):1607–1617. doi: 10.1530/EC-19-0408

Table 2.

Associations of GLP-1 levels in plasma and physical activity parameters.

Model PAEE MVPA CRFa
Difference P Difference P Difference P
Women (n = 623)
 Fasting plasma GLP-1 (% change) 1 0.0 (−0.5; 0.5) 0.923 −12.8 (−32.0; 11.7) 0.278 0.5 (−1.4; 2.5) 0.588
2 0.1 (−0.4; 0.6) 0.654 −10.7 (−30.4; 14.5) 0.372 0.7 (−1.4; 3.0) 0.500
 rAUC0–30 (% change) 1 0.2 (−0.2; 0.6) 0.304 −3.5 (−20.2; 16.8) 0.716 0.1 (−1.4; 1.7) 0.862
2 0.0 (−0.4; 0.4) 0.898 −7.0 (−23.0; 12.4) 0.452 −0.6 (−2.3; 1.1) 0.463
 rAUC0–120 (% change) 1 0.2 (−0.2; 0.7) 0.252 −3.1 (−21.5; 19.5) 0.766 0.2 (−1.5; 2.0) 0.784
2 0.0 (−0.4; 0.4) 0.912 −7.8 (−25.0; 13.3) 0.440 −0.8 (−2.7; 1.1) 0.391
Men (n = 703)
 Fasting plasma GLP-1 (% change) 1 −0.6 (−1.0; −0.3) <0.001 −20.5 (−34.0; −4.4) 0.015 −2.0 (−3.3; −0.7) 0.004
2 −0.5 (−0.9; −0.1) 0.008 −19.5 (−33.0; −3.3) 0.021 −1.9 (−3.3; −0.5) 0.010
 rAUC0–30 (% change) 1 0.2 (−0.1; 0.4) 0.217 16.4 (1.2; 33.8) 0.033 0.0 (−1.0; 1.1) 0.945
2 0.1 (−0.2; 0.4) 0.640 15.8 (0.8; 33.0) 0.038 −0.3 (−1.4; 0.8) 0.581
 rAUC0–120 (% change) 1 0.3 (0.0; 0.6) 0.090 21.0 (3.4; 41.6) 0.018 0.5 (−0.7; 1.7) 0.441
2 0.1 (−0.2; 0.4) 0.454 20.0 (2.6; 40.3) 0.022 0.0 (−1.2; 1.3) 0.987

Estimated percentage change (95% CI) in fasting and glucose-stimulated response GLP-1 in plasma by a unit increase in PAEE (kJ/kg/day), MVPA (h/day), and CRF (mL O2/kg/min). Data are percentage change with 95% CI. P: P value for test of significance of the association. Model 1: Adjusted for age. Model 2: Further adjusted for BMI and peripheral insulin sensitivity (ISI0-120). MVPA is further adjusted for PAEE so an increase in MVPA is at the expense of a decrease in a less intensive physical activity (MET ≤3.0).

aAnalyses of cardiorespiratory fitness levels are based on the subset of participants with CRF data available (n = 793).

CRF, cardiorespiratory fitness; GLP-1, glucagon-like peptide-1; MVPA, moderate-to-vigorous physical activity; PAEE, physical activity energy expenditure; rAUC0–30, peak glucose-stimulated response 30 min after glucose ingestion; rAUC0–120, full glucose-stimulated response 120 min after glucose ingestion.