Figure 5.

pWT apoSOD1^2SH curvature, as determined by Curvalyzer (using chemical shifts referenced to DSS). Curvature may be interpreted as evidence of exchange between distinct conformations, but the absence of curvature does not rule exchange out. The monomeric, rather than dimeric form of apoSOD1^2SH predominates, but here we project the data onto a dimeric SOD1 structure (PDB ID: 2AF2)26 with a semitransparent second subunit in order to illustrate which residues form the dimer interface and present two views (one rotated ∼ 180° relative to the other). Figure prepared using PyMOL28