Fig. 5.

Cholesterol depletion enhances LTβR-triggered expression of NF-κB target genes. a, b mRNA levels of the indicated NF-κB target genes in A549 cells preincubated for 1 h with vehicle or MβCD and then stimulated for 1 h (a) or 4 h (b) with LTβR agonist (Ago) (a, b) or lymphotoxin α1β2 (LTα1β2) (b). Values are presented as fold change versus control – unstimulated and untreated cells, set as 1. Data represent the means ± SEM, n = 4. ns - P > 0.05; *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001 by one sample t-test (in grey) or by Mann-Whitney or Student’s t-test (in black)