Table 1.
Clinical and genetic data of 151 Chinese patients with primary hypertrophic osteoarthropathy
| Patients without GI involvement (N = 125) | Patients with GI involvement (N = 26) | P value | |
|---|---|---|---|
| Age of onset | 14.2 ± 4.2 | 15.4 ± 5.3 | 0.293 |
| Age of diagnosis | 23.7 ± 8. | 25.9 ± 5. | 0.158 |
| Sex (Male) | 92.8%(116/125) | 100%(26/26) | 0.244 |
| Subtype | 0.419 | ||
| 1 | 73.6%(92/125) | 84.6%(22/26) | |
| 2 | 23.2%(29/125) | 11.5%(3/26) | |
| 3 | 3.2%(4/125) | 3.8%(1/26) | |
| Family history | 16.8%(21/125) | 23.1%(6/26) | 0.588 |
| Pachydermia | 88.0%(110/125) | 96.2%(25/26) | 0.507 |
| Cutis verticis gyrate | 52.9%(63/119) | 60.0%(15/25) | 0.444 |
| Eczema | 3.2%(4/124) | 4.0%(1/25) | 0.543 |
| Seborrhea | 57.3%(71/124) | 73.1%(19/26) | 0.157 |
| Acne | 25.0%(29/116) | 48.0%(12/25) | 0.022 |
| Hidrosis | 70.2%(87/124) | 61.5%(16/26) | 0.861 |
| Ptosis | 5.5%(6/109) | 9.5%(2/21) | 0.621 |
| Digital clubbing | 99.2%(124/125) | 96.2%(25/26) | 0.375 |
| Joint hypertrophy | 95.1%(116/122) | 92.3%(24/26) | 0.679 |
| Joint pain | 40.0%(50/125) | 50.0%(13/26) | 0.347 |
| Periostosis | 96%(120/125) | 96.2%(25/26) | 1.000 |
| Osteolysis | 14.2%(17/120) | 19.2%(5/26) | 0.547 |
| Bone age delay | 1.0%(1/103) | 0(0/20) | 1.000 |
| Cranial suture widening/delayed closure of the fontanelle | 3.1%(3/96) | 4.5%(1/22) | 0.567 |
| Hypoevolutism | 0.8%(1/125) | 0(0/26) | 1.000 |
| Anemia | 4.5%(5/112) | 40%(10/25) | < 0.001 |
| Hypoalbuminemia | 0.9%(1/112) | 16.7%(4/24) | 0.003 |
| Myelofibrosis | 0.9%(1/112) | 19.0%(4/21) | 0.002 |
| Mutation of SLCO2A1 | 67.6%(23/34) | 86.7%(13/15) | 0.293 |