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. Author manuscript; available in PMC: 2019 Dec 27.
Published in final edited form as: Int J Hyperthermia. 2019;36(1):712–720. doi: 10.1080/02656736.2019.1631494

Figure 4.

Figure 4.

(a) Concentration of Dox (ng/ml) recovered from HCT116 cells using mass spectrometry for exposure to various media concentrations of Dox at 42 °C. Exposure to Dox in media having concentrations 0.75, 1 and 1.25 μg/ml. Exposure to Dox at 42 °C yielded higher recovered Dox than corresponding exposures at 37 °C (p ≤.04 Welch’s t-test, N = 3 independent experiments). (b) TER vs change of recovered (intracellular) Dox at 42 °C relative to 37 °C shows increased in intracellular Dox did not generate a comparable increase in TER. The red dotted line is a reference drawn to indicate a hypothetical 1:1 behavior. The blue dotted line is a visual aid. Numbers above data points indicated the Dox concentration in media (μg/ml).