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. 2019 Dec 20;7:350. doi: 10.3389/fcell.2019.00350

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Copyright © 2019 Xu, Wang, Li, Heindl, He, Yu, Yang, Ge, Ruan, Jia and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The target genes of LINC-PINT were identified in melanoma cells. (A) Volcano plots of differentially expressed gene. The X axis represented log fold changes. The Y axis represented log p-values. The red points denoted the significantly upregulated genes and blue points denoted the significantly downregulated genes. (B) KEGG analysis of differentially expressed genes between Mock and PINT oe A375 cells. (C) Heat map showed the differentially expressed genes related to cell cycle progression. (D,E) The downregulated cell cycle genes in the microarray were verified in A375 and Mum2B cells by real-time PCR. ^∗p < 0.05, ^∗∗p < 0.01. (F) The expression of LINC-PINT target genes was detected by western blot. Actin were used as internal controls.