Figure 2:

Locations of identified CRAC and CARC motifs within the TM core of Pgp. (A) Front and (B) back views of Pgp viewed from the membrane. CRAC, hCRAC, CARC, and hCARC motifs are colored blue, purple, red, and magenta, respectively, and are labeled with consecutive numbering based on their appearance in the protein sequence. Phosphorous atoms of POPC are shown in gray spheres to denote the location of the bilayer. (C) Amino acid sequences of all TM helices with labeled motifs using the same color scheme as in A and B. Amino acid residues lying outside the TM core are shown in italicized text.