Figure 11.

Cross-tabulation of the Canadian 2015 and Hoyme 2016 FASD Diagnostic Outcomes. Diagnostic concordance (green boxes) between the Canadian 2015 and Hoyme 2016 systems was observed in 41% (569/1,392) of the patients with the majority of the concordance due to 740 of the patients receiving a “Not FASD” diagnosis by both systems. Red bars reflect “FAS with the Face” diagnoses using the Canadian system. Black bars reflect “FASD without the Face” diagnoses using the Canadian system. As a demonstration for how to interpret this figure; 822 patients received a Canadian classification of “Not FASD”. Of the 822 patients, 28 received a diagnosis of “FAS/A?, 70 received a diagnosis of pFAS/AE, 55 received a diagnosis of pFAS/A?, 159 received a diagnosis of ARND/AE and 504 received a classification of “Not FASD” using the Hoyme system. Most of the 159 with FAS/PFAS presented with the relaxed Hoyme FAS facial phenotype. Only 8 of the 159 presented with the Canadian FAS face (4-Digit Code Rank 4). The remaining 151 patients with the Hoyme FAS face presented with the following 4-Digit Face Ranks: Rank 1 normal face 15%, Rank 2 mild face 59%, and Rank 3 moderate face 21%. These relaxed FAS facial phenotypes were used by the Hoyme system to overcome the unknown PAE among the 70 patients diagnosed pFAS/A? and the 28 patients diagnosed FAS/A? Abbreviations: Age yrs; mean age in years at diagnosis.