Table 2.

Prognostic Factors in Univariate and Multivariate Analyses of OS

Variable	Univariate Analysis		Multivariate Analysis
HR (95% CI)	P Value	HR (95% CI)	P Value
Age
≥ 60 vs < 60	1.006(0.988–1.024)	0.542
Gender
Male vs female	0.705(0.423–1.117)	0.182
HBsAg
Negative vs positive	0.970(0.850–1.108)	0.656
AST (U/L)
>40 vs ≤40	1.540(1.080–2.195)	0.017	1.020(0.695–1.497)	0.919
ALT (U/L)
>40 vs ≤40	1.228(0.865–1.745)	0.251
GGT (U/L)
>75 vs ≤75	2.803(1.953–4.024)	<0.001	2.092(1.430–3.062)	<0.001
ALP (U/L)
>110 vs ≤110	1.715(0.800–3.676)	0.165
Albumin (g/L)
>40 vs≤40	0.515(0.363–0.730)	<0.001	0.644(0.441–0.939)	0.022
TB (µmol/L)
>17.1 vs≤17.1	1.078(0.914–1.271)	0.372
AFP (ng/dL)
> 400 vs ≤400	1.000(1.000–1.000)	0.250
PLT(109/L)
> 100 vs ≤100	1.002(1.000–1.004)	0.101
Child-pugh grade
Grade A or B	1.888(0.957–3.725)	0.067
Ascites
Yes vs no	1.525(1.084–2.145)	0.015	1.317(0.946–1.834)	0.103
Liver cirrhosis
yes vs no	0.855(0.573–1.278)	0.445
Lymph node metastasis
yes vs no	1.092(0.572–2.083)	0.790
Portal vein tumor thrombus
Yes vs no	3.425(2.277–5.153)	<0.001	1.827(1.111–3.005)	0.018
Tumor number
Multiple vs single	1.655(1.194–2.294)	0.002	1.432(1.023–2.033)	0.036
Tumor size (cm)
>5 vs ≤5	1.947(1.365–2.777)	<0.001	1.359(0.936–1.973)	0.107
TNM
I+II or III+IV	3.087(2.152–4.427)	<0.001	1.749(1.122–2.725)	0.014