Table 1.
Baseline Characteristics of Patients with Carbapenem-Resistant Acinetobacter Baumannii (CRAB) Pneumonia (N = 160)
| Characteristic (unit) | Carbapenem Combination (n = 83) | Colistin Monotherapy (n = 77) | P value |
|---|---|---|---|
| Male sex | 61 (73.5%) | 53 (68.8%) | 0.515 |
| Age, median ± IQR (years) | 71.9 ± 14.37 | 71.53 ± 14.61 | 0.878 |
| Underlying disease | |||
| Diabetes mellitus | 37 (45.1%) | 27 (35.1%) | 0.302 |
| Hypertension | 51 (61.4%) | 43 (55.8%) | 0.522 |
| Hematologic malignancy | 2 (2.4%) | 2 (2.6%) | 1.000 |
| Solid malignancy | 14 (16.9%) | 13 (16.9%) | 1.000 |
| Chronic kidney disease | 7 (8.4%) | 7 (9.0%) | 0.760 |
| Chronic lung disease | 34 (41.0%) | 28 (36.4%) | 0.505 |
| CNS surgery | 8 (9.6%) | 6 (7.8%) | 0.783 |
| Any surgery | 17 (20.5%) | 12 (15.6%) | 0.538 |
| Neurologic disease | 51 (62.7%) | 39 (50.6%) | 0.151 |
| Previous steroid use | 7 (8.4%) | 3 (3.9%) | 0.332 |
| Previous CARB | 35 (42.2%) | 40 (51.9%) | 0.267 |
| Previous carbapenem use | 57 (71.7%) | 48 (62.3%) | 0.093 |
| Previous hospitalization | 30 (36.1%) | 27 (35.1%) | 1.000 |
| Severity index | |||
| APACHE II Score >24 | 50 (63.3%) | 27 (39.7%) | 0.010 |
| Sepsis | 5 (6.0%) | 1 (1.3%) | 0.212 |
| Initial laboratory data (unit) | Mean ± SD | Mean ± SD | |
| WBC (×103/µL) | 16.13 ± 27.00 | 14.14 ± 7.28 | 0. 533 |
| Hemoglobin (g/dL) | 9.73 ± 1.55 | 9.97 ± 1.44 | 0. 320 |
| Platelet count (/mm3) | 229.12 ± 154.76 | 281.20 ± 133.26 | 0. 024 |
| Segmented neutrophil (%) | 92.67 ± 80.69 | 82.71 ± 13.32 | 0. 287 |
| PT INR (INR) | 1.38 ± 0.51 | 1.47 ± 0.66 | 0. 647 |
| ESR (mm/hr) | 36.25 ± 19.53 | 72.25 ± 31.68 | 0. 101 |
| CRP (g/dL) | 116.20 ± 75.75 | 105.59 ± 85.79 | 0. 408 |
| Procalcitonin (mg/dL) | 3.37 ± 6.83 | 3.65 ± 7.22 | 0. 895 |
| Protein (g/dL) | 5.43 ± 0.89 | 5.80 ± 0.86 | 0. 010 |
| Albumin (g/dL) | 2.6 ± 0.4 | 2.7 ± 0.4 | 0. 457 |
| Total bilirubin (mg/dL) | 1.41 ± 1.69 | 1.09 ± 2.53 | 0. 346 |
| AST (U/L) | 42.95 ± 32.94 | 56.78 ± 162.63 | 0. 352 |
| ALT (U/L) | 43.96 ± 83.24 | 56.78 ± 166.09 | 0. 534 |
| BUN (mg/dL) | 29.37 ± 21.38 | 33.04 ± 49.93 | 0. 577 |
| Creatinine (mg/dL) | 0.99 ± 0.73 | 0.94 ± 0.81 | 0. 667 |
Abbreviations: N, number; IQR, interquartile range; Steroid use, more than 20 mg/day over 14 days; CNS, central nervous system; APACHE, Acute Physiologic Assessment and Chronic Health Evaluation; SD, standard deviation; WBC, white blood cell; PT, prothrombin time; INR, international normalized ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; AST, Aspartate aminotransferase; ALT, Alanine aminotransferase; BUN, blood urea nitrogen.