Table 4.
Risk Factors for 14-Day Mortality in Carbapenem-Resistant Acinetobacter Baumannii (CRAB) Pneumonia: Univariate Analysis
| Characteristic (unit) | Survived (n = 124) | Death (n =36) | P-value |
|---|---|---|---|
| Male sex | 87 (70.2%) | 9 (25%) | 0.572 |
| Age, median ± IQR (years) | 70.29 ± 15.25 | 76.55 ± 10.02 | 0.022 |
| Underlying disease | |||
| Diabetes mellitus | 50 (40.7%) | 13 (36.1%) | 0.167 |
| Hypertension | 74 (59.7%) | 20 (55.6%) | 0.658 |
| Hematologic malignancy | 4 (3.2%) | 0 (0%) | 0.275 |
| Solid malignancy | 20 (16.1%) | 7 (19.4%) | 0.640 |
| Chronic kidney disease | 8 (6.5%) | 3 (8.3%) | 0.694 |
| Chronic lung disease | 46 (37.1%) | 16 (44.4%) | 0.116 |
| CNS surgery | 12 (9.7%) | 2 (5.6%) | 0.441 |
| Any surgery | 22 (17.7%) | 7 (19.4%) | 0.815 |
| Neurologic disease | 72 (58.1%) | 19 (52.8%) | 0.573 |
| Previous steroid use | 5 (4.0%) | 5 (13.9%) | 0.031 |
| Previous CARB | 60 (48.4%) | 15 (41.7%) | 0.477 |
| Previous carbapenem use | 88 (70.7%) | 28 (72.3%) | 0.757 |
| Previous hospitalization | 44 (35.5%) | 13 (36.1%) | 0.945 |
| Severity index | |||
| APACHE II Score >24 | 52 (46.5%) | 25 (71.4%) | 0.064 |
| Sepsis | 4 (3.2%) | 2 (5.6%) | 0.517 |
| Initial laboratory data (unit) | Mean ± SD | Mean ± SD | |
| WBC (×103/µL) | 15.03 ± 22.39 | 15.67 ± 8.01 | 0.867 |
| Hemoglobin (g/dL) | 9.794 ± 1.41 | 10.05 ± 1.78 | 0.375 |
| Platelet count (/mm3) | 265.94 ± 152.79 | 213.69 ± 116.43 | 0.060 |
| Segmented neutrophil (%) | 87.92 ± 66.81 | 87.73 ± 8.11 | 0.987 |
| PT INR (INR) | 1.41 ± 0.57 | 1.52 ± 0.72 | 0.611 |
| ESR (mm/hr) | 56.00 ± 33.11 | 42.00 ± 31.68 | 0.706 |
| CRP (g/dL) | 116.02 ± 84.09 | 94.11 ± 65.70 | 0.152 |
| Procalcitonin (mg/dL) | 3.07 ± 6.42 | 4.58 ± 8.27 | 0.501 |
| Protein (g/dL) | 5.61 ± 0.91 | 5.58 ± 0.86 | 0.883 |
| Albumin (g/dL) | 2.7 ± 0.4 | 2.6 ± 0.40 | 0.163 |
| Total bilirubin (mg/dL) | 1.12 ± 2.03 | 1.74 ± 2.38 | 0.124 |
| AST (U/L) | 52.33 ± 128.52 | 46.86 ± 44.05 | 0.802 |
| ALT (U/L) | 47.22 ± 131.65 | 59.88 ± 122.43 | 0.607 |
| BUN (mg/dL) | 30.28 ± 40.83 | 34.85 ± 24.94 | 0.525 |
| Creatinine (mg/dL) | 0.91 ± 0.67 | 1.18 ± 1.01 | 0.059 |
Abbreviations: N, number; IQR, interquartile range; CNS, central nervous system; Steroid use, more than 20 mg/day over 14 days; APACHE, Acute Physiologic Assessment and Chronic Health Evaluation; SD, standard deviation; WBC, white blood cell; PT, prothrombin time; INR, international normalized ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; BUN, blood urea nitrogen.