Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 23;11:10705–10718. doi: 10.2147/CMAR.S214614

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Ma et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Pathways and functional annotations for SE-associated genes and eigengenes in the yellow module. (A) Prediction of SEs and SE-associated genes. SEs were predicted using the ROSE algorithm, and SE-associated genes were located closest to their respective SEs. A dot plot of the rank of enhancers based on the H3K27ac ChIP-seq signal was generated. In total, 806 SEs and SE-associated genes were predicted (red dots). Blue dots represent typical enhancers (TE). (B) Heat map showing top enrichment clusters for SE-associated genes and eigengenes, one row per cluster, with a discrete color scale representing statistical significance (-Log P). Gray color indicates lack of significance. (C) Metascape enrichment network visualization showing intra-cluster and inter-cluster similarities of enriched terms for SE-associated genes and eigengenes in the yellow module. Each term is represented by a circle node, where its size is proportional to the number of input genes falling into that term, and its color represents cluster identity. Terms with a similarity score > 0.3 are linked by an edge (the thickness of the edge represents the similarity score). One term from each cluster was selected to have its description shown as a label. (D) Enrichment network visualization of results from SE-associated genes and eigengenes in the yellow module, whereby nodes are represented by pie charts indicating association with each input study.