Table 3. Multivariable analysis modeling five-year overall survival for patients with margin-negative and node-negative intrahepatic cholangiocarcinoma.
The optimal threshold for the number of lymph nodes examined, ≥ 3, as determined by maximal chi-square testing, was not significantly associated with five-year overall survival. Patients with missing data for tumor size were excluded (n=23).
| n | % | Hazard Ratio, Five-Year Overall Survival | 95% CI | |
|---|---|---|---|---|
| Number of Lymph Nodes Examined | ||||
| 1 – 2 | 372 | 61.2% | 1.00 | - |
| ≥ 3 | 236 | 38.8% | 0.85 | 0.66 – 1.08 |
| Tumor Size | ||||
| < 5cm | 230 | 37.8% | 1.00 | - |
| ≥ 5cm | 378 | 62.2% | 1.37 | 1.05 – 1.78 |
| Sex | ||||
| Female | 376 | 61.8% | 1.00 | - |
| Male | 232 | 38.2% | 1.58 | 1.25 – 2.01 |
| Metastatic Disease | ||||
| No | 502 | 82.6% | 1.00 | - |
| Yes | 16 | 2.6% | 3.24 | 1.79 – 5.84 |
| Unknown | 90 | 14.8% | 1.15 | 0.83 – 1.61 |
| Vascular Invasion | ||||
| No | 291 | 47.9% | 1.00 | - |
| Yes | 170 | 28.0% | 1.51 | 1.12 – 2.02 |
| Unknown | 147 | 24.2% | 1.34 | 0.87 – 2.07 |
| Multiple Lesions | ||||
| No | 375 | 61.7% | 1.00 | - |
| Yes | 67 | 11.0% | 2.49 | 1.78 – 3.47 |
| Unknown | 166 | 27.3% | 1.31 | 0.89 – 1.92 |