Table 2.
Infection Characteristics
| Characteristic | Total Cohorta N = 203 | CRE Infectiona N = 117 | Pseudomonas spp Infectiona N = 63 |
|---|---|---|---|
| Hospital-acquired infection | 117 (57.6) | 71 (60.7) | 38 (60.3) |
| Hours from admission to culture collection | 3 (2–16) | 6 (2–17) | 73 (2–13) |
| Infection Source | |||
| Primary bacteremia | 10 (4.9) | 7 (6.0) | 1 (1.6) |
| Respiratory | 76 (37.4) | 39 (33.3) | 38 (60.3) |
| Intra-abdominal | 38 (18.7) | 26 (22.2) | 3 (4.8) |
| Skin and soft tissue | 18 (8.9) | 8 (8.8) | 6 (9.5) |
| Osteoarticular | 14 (6.9) | 7 (6.0) | 6 (9.5) |
| Urine | 40 (19.7) | 24 (20.4) | 7 (11.1) |
| Prosthetic device | 2 (1.0) | 2 (1.7) | 0 |
| Intravenous catheter | 4 (2.0) | 3 (2.6) | 2 (3.2) |
| Otherb | 1 (0.5) | 1 (0.9) | 0 |
| Positive blood cultures | 22 (10.8) | 10 (8.5) | 3 (4.8) |
| Organism | |||
| Enterobacteriacea | 159 (78.3) | 117 (100) | |
| Klebsiella pneumoniae | 89 (43.8) | 74 (63.2) | |
| Klebsiella oxytoca | 8 (3.9) | 5 (4.3) | |
| Escherichia coli | 23 (11.3) | 17 (14.5) | |
| Enterobacter spp | 29 (14.3) | 15 (12.8) | |
| Proteus mirabilis | 8 (3.9) | 1 (0.9) | |
| Citrobacter spp | 9 (4.4) | 5 (4.3) | |
| Serratia marcescens | 6 (3.0) | 4 (3.4) | |
| Providentia stuarti | 4 (2.0) | 0 | |
| Morganella morganii | 4 (2.0) | 0 | |
| Pseudomonas spp | 63 (31.0) | ||
| Acinetobacter sppc | 12 (5.9) | ||
| Stenotrophomonas maltophiliad | 5 (2.5) | ||
| Gram positive | 30 (14.8) | ||
| Polymicrobial infection | 48 (23.6) | 30 (25.6) | 17 (27.0) |
| K pneumoniae CZA MIC (mg/L) | |||
| MIC50 | 1e | 1f | |
| MIC90 | 2e | 4f | |
| Pseudomonas aeruginosa CZA MIC (mg/L) | |||
| MIC50 | 2g | ||
| MIC90 | 6g |
Abbreviations: CRE, carbapenem-resistant Enterobacteriaceae; CZA, ceftazidime-avibactam; MIC, minimum inhibitory concentration.
aAll values represent number (%) or median (interquartile range).
bPerinephric abscess.
cEleven of 12 patients had polymicrobial infections and received additional other antibiotics targeting Acinetobacter spp. The remaining patient had monomicrobial Acinetobacter urinary tract infection. They received CZA (surprisingly, MIC 8 mg/mL) plus minocycline. The rationale for using CZA was not explicitly stated.
dAll patients had polymicrobial infections and received additional other antibiotics targeting S maltophilia.
en = 51 isolates tested.
fn = 43 isolates tested.
gn = 19 isolates tested.