Frequency analysis results for 2D (a,b) and 3D (c,d). In both cases, the distribution is described using two parameters: α (a,c) and β (b,d). Error bars are given by the standard deviation of the result evaluated over the population of mice. Significance levels are represented by a triangles for age groups, + for genotypes and * for treatments, with one, two, and three symbols for p <0.05, p < 0.01, and p <0.0001, respectively.