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. Author manuscript; available in PMC: 2020 Jun 21.
Published in final edited form as: Adv Funct Mater. 2019 Apr 22;29(25):1900566. doi: 10.1002/adfm.201900566

Figure 4. Molecular imaging of immune checkpoint PD-L1 based on the renal-excreted NIR-II fluorophores.

Figure 4.

a) Molecular structure and molecular dynamics simulation of renal-excreted NIR-II fluorophore IR-BGP6. b) Renal excretion behavior of IR-BGP6. Most IR-BGP6 went to bladder after intravenous injection. c) Scheme of conjugation of PD-L1 mAb onto IR-BGP6. d) Non-invasive molecular imaging of PD-L1 using anti-PD-L1-BGP6 probe. Without attachment of PD-L1 mAb negligible IR-BGP6 accumulated within the MC38 tumors. Reproduced with permission[6b]. Copyright 2018, John Wiley and Sons.