Skip to main content
. 2019 Dec 9;130(1):480–490. doi: 10.1172/JCI126595

Figure 2. Islet-specific CD8+ T cell frequency and phenotype do not differ between HCs and individuals with T1D.

Figure 2

HCs (n = 20) were assayed with our Tmr-CyTOF panel and included in the DISCOV-R analysis as in Figure 1. (A) Frequency of islet-specific (Tmr+) cells within total CD8+ T cells was assessed and compared for HCs (n = 20) and T1D subjects (n = 46) using a Mann-Whitney U test. (B) Frequency of islet-specific CD8+ T cells among the 3 common islet-specific clusters was assessed for HCs (n = 13) and individuals with T1D (n = 39) with 5 or more Tmr+ events using 2-way ANOVA with Sidak’s test for multiple comparisons. Data represent the mean ± SD. TM, transitional memory.