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. 2019 Nov 25;130(1):247–257. doi: 10.1172/JCI129167

Figure 7. The recruitment of BA-H during cold exposure declines with age.

Figure 7

(A) AdipoChaser-LacZ male mice were kept on normal chow until 30 or 60 weeks of age. Mice were then exposed to 6°C for 7 days while treated with dox-containing chow diet. (B) Representative X-gal staining of BAT from mice of different age exposed to 6°C. Scale bar: 50 μm. (C) Quantification of the percentage of LacZ+ brown adipocytes in the total brown adipocytes. n = 11 mice (10 weeks old); n = 5 mice (30 weeks old); n = 10 mice (60 weeks old). **P < 0.01. Statistical significance was assessed using a 1-way ANOVA followed by Tukey’s multiple comparisons test. All images are representative of 3 independent experiments.