Figure 6. Filovirus and LASV viremia in cynomolgus macaques challenged i.m. with LASV, EBOV, SUDV, or MARV.

Quadrivalent (Q-V) or control (HIVgag) rVSV vaccinated macaques were challenged i.m. with 1000 PFU (A and E) LASV (strain 0043/LV/14), (B and F) EBOV (strain Kikwit), (C and G) SUDV (strain Gulu), or (D and H) MARV (strain Angola). Post-challenge viremia was monitored by infectious plaque assay (A–D) or RT-qPCR (E and F). Limit of detection (LOD) for LASV, EBOV, SUDV, and MARV genome equivalent qRT-PCR is log₁₀ 4, log₁₀ 3, log₁₀ 3, and log₁₀ 4, respectively.