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. 2019 Nov 25;130(1):214–230. doi: 10.1172/JCI130711

Figure 2. Next-generation sequencing summary for the human TCRA/D locus.

Figure 2

(A) Frequency of Vδ1, Vδ2, γδ T cells and MAITs as determined by TCR sequencing (y axis) or flow cytometry (x axis, fraction of CD3+ T cells) in blood from HCs. (B) Percentage of γδ T cells, MAITs, iNKTs, and GEMs in blood from HCs, HIVpos subjects, and HIVneg subjects with active TB. (C) Percentage of DURTs in blood from HCs (n = 12) and in blood (n = 11) or lung tissue (n = 17) from HIVpos subjects with active pulmonary TB. The TCRδ sequences encoded by the Vδ1, Vδ2, or Vδ3 or Vδ* (Vδ4+Vδ5+Vδ6+Vδ7+Vδ8) are identified by different shades of red. The non-DURTs are defined as “conventional.” (D) Percentage of Vδ1, Vδ2, or Vδ3, MAIT, iNKT, and GEM T cells in blood from HCs and blood and lung tissue from HIVneg subjects with active pulmonary TB. (E) Percentage of total GEM, MAITs, iNKT, and γδ T cells in lung lesion types A, B, and C. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001, by Kruskal-Wallis 1-way ANOVA with Dunn’s multiple comparisons test (B) and 2-way ANOVA with Tukey’s multiple comparisons test (D and E).